FSHR anticorps

N° du produit ABIN6296013

Cet anticorps anti-FSHR est un anticorps Souris Monoclonal détectant FSHR dans IHC, IF et FACS. Adapté pour Humain.

Aperçu rapide pour FSHR anticorps (ABIN6296013)

Antigène: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FSHR est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-FSHR anticorps

Fonction: Mouse anti-Human FSH Receptor Antibody [Sodium Azide Free]

Specificité: Cytoplasmic, cell surface

Purification: A human recombinant protein was used as the immunogen for this FSHR antibody.

Immunogène: A human recombinant protein was used as the immunogen for this FSHR antibody.

Information d'application

Indications d'application: FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL for 30 min at RT

Restrictions: For Research Use only

Stockage

Buffer: In 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Détails sur FSHR

Antigène: FSHR (Follicle Stimulating Hormone Receptor (FSHR))

Autre désignation: Follicle-stimulating hormone receptor

Sujet:

Target Description: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its alpha and beta subunits. While the alpha subunit of FSH is involved in the binding of FSH to the receptor, the beta subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome, a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

Gene Symbol: FSHR///LGR1

ID gène: 2492

UniProt: P23945

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Platelet-derived growth Factor Receptor Signaling